Sunday's games London Irish make one change to the side which started against Newcastle last Sunday. Rob Hoadley plays in place of Nils Mordt at inside centre after recovering from a viral infection.
Rob Hardwick (thumb), Kieran Roche (leg), Chris Sheasby (eye) and Ryan Strudwick (leg) are all out.
Sale have named Scotland World Cup duo Bryan Redpath and Jason White in their side.
Saracens head coach Rod Kafer has given a start to World Cup winner Richard Hill. New signing Cobus Visagie will take his place in the front row along with Robbie Russell. Alex Codling returns in place of Kris Chesney in the second row.
Denis Cech makes his first start for the club on the wing and Paul Bailey switches to the centre, replacing Nicky Little. Thomas Castaignede plays at fly-half.
Rotherham will field an unchanged side for the first time this season.
Guy Easterby starts on the bench after returning from World Cup duty with Ireland. Jacob Rauluni continues as captain and there is no place in the squad for new signing Andy Long.
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