Astana's Alexandre Vinokourov and Andreas Kloeden prepare for stage six after both riders picked up injuries on Thursday

Vinokourov is moving shakily at the start with stitches in his knee, while Kloeden is labouring with a cracked coccyx

Britain's Bradley Wiggins launches a solo break from the pack soon after the start of the 199.5km stage to Bourg-en-Bresse

Yellow jersey holder Fabian Cancellara has a word with his team car as Wiggins opens up a 13-minute lead at the front

After the drama and crashes on Thursday, the Tour makes comparatively sedate progress towards the Alps

But the peloton keep up on the pressure on Wiggins up in front and claw back time over the two climbs of the day

Wiggins starts to struggle on his own and the Olympic pursuit champion's lead slips to under two minutes with 30km to go

After leading from the 2km mark and battling into a headwind, there is nothing Wiggins can do to stay ahead of the pack

Vinokourov keeps up with the pace but looks to be struggling as the peloton finally catch up with Wiggins with 7km to go

Tom Boonen of Quick Step comes out on top by a bike length after a bunch sprint to the line in Bourg-en-Bresse

Boonen earns himself the green jersey with his stage win, while Oscar Freire finishes second and Erik Zabel in third

Wiggins picks up a jersey for the day's most aggressive ride as the Tour prepares to head to the mountains on Saturday