Wegmann made his decisive move late in the race

The German clocked a time of five hours, five minutes and 36 seconds for the 207km stage after breaking away with 15km to go.

The Gerolsteiner rider edged out Frenchman Thomas Voeckler and Spain's Egoi Martinez on the line.

British rider Bradley Wiggins finished in the main pack 13 seconds back.

Thanks to time bonuses, Wegmann now leads overall, with Martinez second five seconds back on the same time as the former leader and prologue winner, American Dave Zabriskie.

"I am quite surprised we managed to keep the sprinters at bay," said Wegmann, a former winner of the King of the Mountains in the Giro d'Italia.

"It was a tough stage to do. I haven't raced for five weeks, so this is a good sign for the Tour de France."

Stage results
1. Fabian Wegmann (Ger/Gerolsteiner) 5:05:36"
2. Thomas Voeckler (Fra/Bouygues Telecom) same time
3. Egoi Martinez (Sp/Discovery Channel) s.t.
4. Francisco Mancebo (Sp/AG2R) +2"
5. Danilo Napolitano (Ita/Lampre) +13"
6. Sebastian Siedler (Ger/Milram) s.t.
7. Chris Horner (U.S./Davitamon - Lotto) s.t.
8. Jose Joaquin Rojas (Sp/Liberty Seguros) s.t.
9. Philippe Gilbert (Bel/Francaise des Jeux) s.t.
10. Mauro Da Dalto (Ita/Liquigas) s.t.

Selected other
156. Bradley Wiggins (GB/Cofidis) +13"

Overall classification
1. Fabian Wegmann (Ger/Gerolsteiner) 5:11:23"
2. David Zabriskie (U.S./Team CSC) +1"
3. Thomas Voeckler (Fra/Bouygues Telecom) +3"
4. George Hincapie (U.S./Discovery Channel) same time
5. Egoi Martinez (Sp/Discovery Channel) +5"
6. Thor Hushovd (Nor/Credit Agricole) +7"
7. Francisco Mancebo (Sp/AG2R) same time
8. Stuart O'Grady (Aus/Team CSC) s.t
9. Sebastian Lang (Ger/Gerolsteiner) +8"
10. Joost Posthuma (Ned/Rabobank) +9"

Selected other
25. Bradley Wiggins (GB/Cofidis) +16"