LPGA Tour rookie Brandi Jackson hit a six-under-par 66 to lead by one shot in the Safeway Classic in Oregon. Britain's Janice Moodie, who said she had been inspired by Europe's opening day Ryder Cup success, is one of three players in second place on five under.
World number one Annika Sorenstam, who has won the event for the last two years, shot a two-under-par 70.
A thunderstorm at the Portland course meant play had to be suspended for an hour and a half.
Britain's Karen Stupples had nine birdies in her round of 68 - but also had three bogeys and a double-bogey.
Catriona Matthew, a winner in Ohio last month, Becky Morgan and Kathryn Marshall, all on 71, were the other Britons to finish under par.