The Adventures of Batmanu Eboué and RobinVanPersie
French international Sagna will miss Arsenal's FA Cup tie against Leeds on Saturday, the first leg of the Carling Cup semi-final against Ipswich, and the Premier League trip to West Ham.
His place in the line-up for the Leeds game is likely to go to Emmanuel Eboue.
Wenger confirmed he would make changes to the line-up for the game, with a fit-again Kieran Gibbs and midfielder Aaron Ramsey, newly returned from a loan at Nottingham Forest, available to play.
"We will rotate. There are going to be changes, many changes," Wenger added.
"I have somewhere in my mind that I will make changes, but I don't know who will play.
"I believe that Samir Nasri and Robin van Persie could be short for Saturday.
"They have kicks - van Persie on the hip and Nasri on the ankle. It is a question of days.
"They have a chance to recover in time, but I will certainly rest van Persie and maybe Nasri."
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