Macclesfield dumped Blackpool out of the Carling Cup after the Seasiders missed a succession of chances.
Ben Burgess had a goal disallowed for offside and Ian Evatt hit the crossbar before Shaun Brisley shot through the legs of Blackpool keeper Matt Gilks.
Blackpool's Gary Taylor-Fletcher then headed over from four yards before captains Terry Dunfield and Keith Southern were dismissed for fighting.
Martin Gritton headed home from Jamie Tulley's free-kick for Town's second.
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