Favourites Chelsea and Manchester United were both handed home ties in the draw for the FA Cup fifth round. Chelsea will host Norwich after the Canaries beat Blackpool, while United will face Premiership rivals Reading.
Two other all-Premiership matches came out of the hat, with Spurs away to Fulham and Blackburn travelling to the Emirates Stadium to face Arsenal.
Preston will host neighbours Manchester City, with matches due to take place on the weekend of 17 and 18 of February.
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And North End boss Paul Simpson, whose side overcame Championship rivals Crystal Palace in the last round, was relishing a tie against one of his old clubs.
"It's a fantastic draw for us," he said. "I have wonderful memories of my time at City and we hope we'll get a full house at Deepdale for it. It's a great day to look forward to.
"It will be a very tough game. But to be at home gives us a really good opportunity, if we carry on with our home form, to continue to the next round."
One Championship side is guaranteed to reach the last eight, after Plymouth were drawn at home to Derby.
606 DEBATE: What is your reaction to the draw?
Chelsea v Norwich
Watford v Ipswich
Preston v Man City
Plymouth v Derby County
Man Utd v Reading
Arsenal v Blackburn
Middlesbrough v West Bromwich Albion
Fulham v Tottenham
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