The system involves an extra official standing on the side of each goal assisting the referee and two touchline assistants by communicating through headsets.
European football's governing body Fifa and its rule-making arm, the International Football Association Board, ordered a trial of the system last year as an alternative to using video replays.
Uefa used the five-official system at last year's under-19 European Championship qualifying matches in Slovenia, Hungary and Cyprus, where it was hailed a success.
Having an extra pair of eyes monitoring play in each area had a preventive effect and promoted better decision making on suspected fouls.
Players were less prone to shirt-pulling at corners and free kicks, diving in the area and dissent, it reported.
The announcement that matches in the Europa League will be played with the experimental system came after a two-day meeting of Fifa's executive committee in Nassau.
Qualifying-round matches for the Europa League begin in July.
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