Their best chance of the half fell to Mantzios, who brought a fine save from Lopez.
Villarreal served notice of their threat, however, when Ibagaza put the ball in the net only to have the goal ruled out for a foul in the build-up.
But the Argentine made no mistake four minutes into the second-half when he curled a shot from the edge of the penalty area past Galinovic.
Pana fought back with a series of corners and they were rewarded for their pressure six minutes later when Mantzios powered a header past Lopez for his fourth goal in six games.
But it was substitute Llorente who had the final say when he made no mistake by finishing off Ibagaza's dinked pass to send the Spanish side through.
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