The 28-year-old, who has struggled to hold down a regular place this season, pulled a leg muscle in training last week.
Barca forwards Thierry Henry and Bojan Krkic picked up knocks in the European game against Schalke on Wednesday, while midfielder Andres Iniesta has a knee problem.
Portuguese midfielder Deco has missed the last month with a calf injury, but he may still be fit for the first leg.
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