Saturday's Premiership round-upLeaders Arsenal dropped their first points of the season when they were held to a 1-1 draw by Premiership newcomers Portsmouth.
The Gunners, who went into the game with a 100% record, were far from impressive as their lead at the top of the table was reduced to one point.
August's player-of-the-month, Teddy Sheringham, fired Pompey ahead before Thierry Henry levelled for the Gunners with a controversial penalty.
Manchester United laboured to a 2-0 win at Charlton Athletic with striker Ruud van Nistelrooy scoring both goals.
Paolo di Canio made his home debut for Charlton, but the first half was a dismal affair with few scoring chances.
Van Nistelrooy bundled home his first goal in three matches after Charlton failed to clear a free-kick on his 100th start for the Red Devils.
Charlton then had Jason Euell for a second yellow card before Van Nistelrooy made certain for United with his second goal.
Chelsea powered to a 4-2 victory over Tottenham at Stamford Bridge.
Freddie Kanoute put Spurs ahead as Glenn Hoddle's men looked for their first win over the Blues in 26 attempts.
Chelsea hit back with two goals in as many minutes through Frank Lampard and Adrian Mutu to take control.
Mutu added a second to put Chelsea firmly in control mid-way through the second period.
Kanoute pulled one back before Jimmy Floyd Hasselbaink made sure of the points for Chelsea.
Everton and Newcastle had to settle for a point apiece in a stormy 2-2 draw at Goodison Park.
England sensation Wayne Rooney failed to last to half time after limping off with an injury, while Newcastle's Laurent Robert was sent off for collecting two yellow cards.
Everton also went down to 10 men when Gary Naysmith hauled down Kieron Dyer and the Toffees defender was dismissed by referee Rob Styles.
Alan Shearer scored from the penalty spot but the Magpies' joy was short-lived when Tomasz Radzinski clipped the ball home off the woodwork.
There was more controversy when Newcastle were awarded a second spot-kick and Shearer again made no mistake.
Just as Newcastle thought they had won, Everton levelled from the penalty spot through ex-Newcastle striker Duncan Ferguson.
Liverpool enjoyed an excellent 3-1 triumph at Blackburn Rovers.
Liverpool, who lost striker Milan Baros with a broken ankle injury, fell behind early on to a stunning Matt Jansen goal.
But Liverpool hit back straight away with Michael Owen levelling from the penalty spot.
Lucas Neill was sent off for a two-footed challenge on Jamie Carragher and a second goal from Owen and a late Harry Kewell strike left Liverpool victorious.
Southampton heaped more misery on struggling Wolves as they won 2-0 at St Mary's Stadium.
England striker James Beattie fired home from the penalty spot in the first half and then added the second after being set-up by Kevin Phillips to leave Dave Jones' side rooted to the bottom of the table.
Bolton Wanderers recorded their first victory of the season at the expense of fellow strugglers Middlesbrough at the Reebok Stadium.
Kevin Davies put Bolton ahead when he slipped his marker to power the ball home following a corner from Giannakopulos.
Boro had plenty of the ball but the game was put beyond them when Bruno N'Gotty added the Trotters' second.