Rob Atkinson and Danny Boshell scored to give relegation-threatened Grimsby a lifeline - but their hero was on-loan goalkeeper Wayne Henderson.
Notts were denied by several fine saves by Henderson, while Boshell cleared Delroy Facey's header off the line.
Defender Atkinson then soared to head in a corner from Peter Sweeney.
And with Notts pressing foward, Boshell went clear to score a goal that sealed Grimsby's win and Luton's relegation from the League.
Notts County: Pilkington, Picken, Edwards, Johnson (Canham 76), Clapham, Hamshaw, Thompson, Butcher, Weston, Forte, Facey. Subs Not Used: Forrester, Strachan, Fairclough, Hunt.
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Booked: Thompson, Johnson.
Grimsby: Henderson, Stockdale, Bennett, Atkinson, Widdowson, Boshell, Sweeney, Hegarty, Akpa Akpro (Forbes 71), Proudlock, Conlon. Subs Not Used: Lund, Heywood, Bore, Jarman.
Goals: Atkinson 52, Boshell 79.
Att: 5,890.
Ref: Mark Haywood (W Yorkshire).
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