Victory for Rochdale lifted them into the automatic promotion places while leaving Grimsby in relegation trouble.
A wicked deflection helped Adam Rundle's 20-yard strike wrong-foot Mariners keeper Wayne Henderson.
Rundle then released Adam Le Fondre who raced clear to score while Grimsby's defenders appealed for offside.
Town's Adrian Forbes had a shot tipped onto the bar before boss Mike Newell was sent to the stands at half-time for arguing about Dale's second goal.
Rochdale: Fielding, Wiseman, Ramsden, Stanton, Kennedy, Adams (Thompson 64), Toner, Keltie, Rundle, Le Fondre (Dagnall 82), Thorpe (McEvilly 74). Subs Not Used: McArdle, William Buckley.
Booked: Stanton.
Goals: Rundle 5, Le Fondre 12.
Grimsby: Henderson, Clarke, Bennett, Atkinson, Newey (Elliott 72), Jarman, Sinclair (Boshell 46), Kalala, Hegarty, Proudlock (Akpa Akpro 61), Forbes. Subs Not Used: Heywood, Montgomery.
Booked: Clarke, Boshell, Henderson.
Att: 3,076
Ref: Trevor Kettle (Rutland).
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