Aaron Downes second-half goal sunk Port Vale and earned Chesterfield their first league win in seven games.
Downes met Darren Currie's cross with an unstoppable header after 54 minutes.
Vale captain Marc Richards crashed a shot against the bar after 20 minutes, but was sent off before the interval when he appeared to punch Downes.
Gregor Robertson should have extended Chesterfield's lead before Vale launched a fightback that almost brought Kyle Perry a late leveller.
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Sent Off: Richards (41).
Booked: Owen, Davidson, Dodds.
Booked: Hall, Harsley, Lowry.
Goals: Downes 54.
Att: 5,011
Ref: Craig Pawson (Sheffield).
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