Matt Harrold and Lewis Spence scored as Wycombe extended their unbeaten run to remain top of the League Two table.
A poor pass from County's Jonathan Forte resulted in Angelo Balanta cutting the ball back for Harrold to score his sixth in four games.
Spence struck with a free-kick from 20 yards to ensure Wycombe stretched their unbeaten run back to April.
Wycombe goalkeeper Scott Shearer had a quiet night but did save headers from Jamie Forrester and Mike Edwards.
Notts County: Hoult, Mayo, Edwards, Thompson, Clapham, Neal, Strachan, Butcher, Forrester (Weir-Daley 71), Facey, Forte.Subs Not Used: Pilkington, Canham, Hunt, Nowland.
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Wycombe: Shearer, Hunt, Williamson, McCracken, Woodman, Moussa, Doherty, Spence, Balanta (Phillips 86), Harrold, Zebroski.Subs Not Used: Young, Johnson, Mousinho, Vieira.
Booked: Balanta.
Goals: Harrold 47, Spence 65.
Att: 2,964
Ref: Craig Pawson (Sheffield).
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