Danny Boshell struck from 20 yards to boost Grimsby's promotion hopes, but push Mansfield closer to relegation.
The visitors took the lead when Peter Till's shot found its way through a crowd of players, but Nathan Arnold levelled with a great turn and finish.
Mansfield had chances to take the lead before Boshell fired into the top corner from 20 yards.
While Grimsby have play-off hopes, Mansfield are five points from safety and have not won at home this year.
Mansfield: White, Mullins, Baptiste, Buxton, Jelleyman, Hamshaw (Louis 83), Dawson, D'Laryea (Horlock 77), Atkinson (Wainwright 66), Arnold, Michael Boulding. Subs Not Used: Muggleton, Briggs.
Goal: Arnold 49.
Booked: Jelleyman.
Grimsby: Barnes, Newey, Fenton, Atkinson (Bennett 65), Clarke, Till, Bolland (Jones 65), Boshell, Hegarty, Butler, North (Hunt 46).Subs Not Used: Montgomery, Taylor.
Goals: Till 32, Boshell 74.
Booked: Fenton.
Att: 2,616
Referee: Andy Hall (W Midlands).
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