Goals in each half took Peterborough back to the top of the table.
Aaron McLean headed Peterborough in front on 10 minutes after a cross by Claude Gnapka but Brentford had several chances to level the scores.
Glenn Poole shot wide, Nathan Elder headed over and Alan Bennett's looping effort was tipped over the bar.
McLean set up Craig Mackail-Smith to make it 2-0 before Alan Connell pulled one back for the Bees, who had a decent late penalty shout turned down.
Brentford: Simon Brown, Pead, Bennett, Osborne, Dickson,
Shakes, Smith, Stone (Mousinho 75), Poole, Connell, Elder.
Subs Not Used: Hamer, Reid, Charles, Wayne Brown.
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