Macclesfield striker Colin Heath suffered a suspected broken leg in a comprehensive defeat at Wycombe. Heath and Wycombe keeper Ricardo Batista were both stretchered off following a collision.
Tommy Doherty's stunning 25-yard free-kick fired Wycombe ahead, and Russell Martin's long-range effort doubled the lead.
Matt Bloomfield scored the third and Macc were reduced to 10 men when Jordan Hadfield received a second yellow card.
Wycombe: Batista (Young 12), Martin, Stockley, Crooks, Golbourne, Doherty, Bloomfield, Grant, Ainsworth (Palmer 56), Mooney (Easter 66), McGleish.
Subs Not Used: Christon, Gregory.
Booked: Doherty.
Goals: Doherty 40, Martin 54, Bloomfield 65.
Macclesfield: Lee, Regan, Morley, Swailes, Bullock, Navarro (Murray 56), Heath (Doyle 12), McIntyre, Hadfield, Murphy, Miles (Tipton 72).
Subs Not Used: Jennings, Scott.
Sent Off: Hadfield (78).
Booked: Navarro, Miles, Hadfield, Murray.
Att: 5,450
Ref: P Miller (Bedfordshire).