MK Dons manager Martin Allen engineered a second-half recovery as they came from behind to beat Wrexham. Wrexham skipper Neil Roberts opened the scoring when he forced the ball home following two blocked efforts.
The turning point came with Izale McLeod's arrival after the interval, as within 38 seconds of the restart he had levelled the scores with a low shot.
McLeod then turned provider, setting up Sean O'Hanlon to sweep home a 72nd minute winner for MK Dons.
Wrexham: Ingham, Roche (Spender 71), Steve Evans (Mackin 80), Gareth Evans, Mike Williams, Mark Jones, Crowell, Ferguson, Llewellyn, Done, Roberts (Newby 64).
Subs Not Used: Michael Jones, McAliskey.
Booked: Done, Gareth Evans, Mark Jones, Mackin.
Goals: Roberts 20.
Milton Keynes Dons: Baines, Jamie Smith, Diallo, O'Hanlon, Lewington, McGovern, Mitchell, Wilbraham, Dyer (Chorley 81), Platt, Taylor (McLeod 45).
Subs Not Used: Bankole, Crooks, Edds.
Booked: O'Hanlon.
Goals: McLeod 46, O'Hanlon 77.
Att: 3,828
Ref: U Rennie (S Yorkshire).