Macclesfield increased the pressure on Stockport manager Chris Turner with a massive win over their local rivals. County were down to 10 men after 17 minutes when Tes Bramble was sent off for following a foul on Danny Swailes.
And it got worse when Clyde Wijnhard and Jon Parkin gave Macclesfield a two-goal lead before half-time.
The pair were also on target after the break with Martin Bullock and John Miles also finding the net against League Two's bottom club.
Macclesfield: Fettis, Navarro, Morley, Swailes (Teague 19), Harsley, Whitaker (Miles 71), McIntyre, Bullock, Sandwith, Wijnhard (Townson 71), Parkin.
Subs Not Used: Deasy, Smart.
Booked: Whitaker.
Goals: Wijnhard 41, Parkin 43, Bullock 59, Parkin 63, Wijnhard 64, Miles 86. Stockport: Spencer, Greenwood, Clare, Raynes, Robinson (Crowe 45), Hamshaw, Boshell, Briggs, Singh, Bramble, Easter.
Subs Not Used: Ikeme, Malcolm, Dje, Allen.
Sent Off: Bramble (17).
Booked: Easter.
Att: 4,553
Ref: D Deadman (Cambridgeshire).