Northampton's relegation worries increased after losing to Southend.
Southend's Jean-Francois Christophe broke the deadlock when heading home Franck Moussa corner.
Northampton levelled with Adebayo Akinfenwa converting Danny Jackman's cross but Southend's Theo Robinson beat Chris Dunn at his near post for 2-1.
Lee Barnard increased the lead when he rounded Dunn for 3-1 before Aleksandar Prijovic pulled back a consolation after firing home from 15-yards.
Northampton: Dunn, Watts, Hughes, Doig, Hodgkiss (Anya 63), Crowe, Gilligan (Prijovic 63), Holt, Jackman, Akinfenwa, Vernon (Osman 78). Subs Not Used: Walker, Dyer.
Goals: Akinfenwa 50, Prijovic 80.
Southend:
Mildenhall, Francis, Dervite, Clarke, Barrett, Scannell (Betsy 69), McCormack, Christophe, Moussa, Barnard, Robinson. Subs Not Used: Joyce, Sankofa, Freedman, Laurent.
Booked: Christophe, Clarke.
Goals: Christophe 38, Robinson 56, Barnard 60.
Att: 5,190
Ref: Chris Sarginson (Staffordshire).
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