Leeds survived a Scunthorpe fightback to secure all three points and move back into the play-off places.
Jermaine Beckford opened the scoring against his old club from Jonny Howson's cross, before Bradley Johnson saw his deflected shot make it 2-0.
But Gary Hooper capitalised on some poor defending to pull one back, before he ran through unchallenged to level.
Beckford hammered in from 12 yards to win it before Leeds had Howson sent off for two bookable offences.
Leeds: Ankergren, Douglas, Marques, Naylor, Parker, Kilkenny (Trundle 56), Howson, Delph, Snodgrass, Beckford, Robinson (Johnson 15), Trundle (Michalik 88). Subs Not Used: Lucas, Grella.
Sent Off: Howson (80).
Booked: Johnson, Howson.
Goals: Beckford 33, Johnson 38, Beckford 69.
Scunthorpe: Murphy, Byrne, Crosby (Thompson 85), Pearce, Mills, Sparrow, Togwell, McCann, Woolford (Hayes 56), Hooper, Odejayi (Lansbury 81). Subs Not Used: Lillis, Wright.
Booked: Togwell, Pearce, McCann.
Goals: Hooper 42, 52.
Att: 24,921.
Ref: Iain Williamson (Berkshire).
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