Captain Stephen Purches's decisive goal clinched only a third home win this season for Leyton Orient and kept Crewe deep in relegation trouble.
The right-back capped a fine move involving Sean Thornton and Adam Boyd when he broke in from the right and fired home a rising 15-yard shot.
Crewe keeper John Ruddy tipped over an almost carbon-copy effort from Purches.
Alex striker Tom Pope had a header ruled out for offside and the visitors also had a late penalty claim rejected.
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Booked: Smith.
Goals: Purches 11.
Crewe: Ruddy, Brayford, Lawrence, Broomes, Jones, Miller, Baudet (Carrington 61), Woodards (Zola 81), Grant, Pope (Moore 75), Donaldson. Subs Not Used: Collis, Abbey.
Booked: Baudet, Jones.
Att: 3,705
Ref: Clive Penton (Sussex).
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