Aaron Brown's early strike gave 10-man Yeovil a 1-0 victory at Southend.
The centre-back volleyed home from close-in after six minutes after Southend goalkeeper Steve Mildenhall failed to collect a free-kick.
Yeovil lost Aidan Downes to a straight red card shortly after the break for a two-footed challenge on Johnny Herd.
Southend pushed for an equaliser but Yeovil keeper Josh Wagenaar kept his side in front with several fine saves, notably denying Franck Moussa.
Southend: Mildenhall, Sankofa (Scannell 83), Francis, Barrett, Herd, Betsy (Robinson 46), Grant, Christophe (O'Keefe 82), Moussa, Barnard, Walker. Subs Not Used: Joyce, Ademeno.
Booked: Betsy, Walker.
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Yeovil: Wagenaar, Alcock, Brown, Forbes, Smith, Downes, Peltier (Murtagh 46), Schofield, Welsh (Jones 67), Warne (Tomlin 30), Rodgers. Subs Not Used: McCollin, Cox.
Sent Off: Downes (53).
Booked: Rodgers, Alcock.
Goals: Brown 6.
Att: 6,409
Ref: Paul Taylor (Hertfordshire).
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