Striker Steve Gillespie scored against his former side to help Colchester beat 10-man Cheltenham.
Visiting keeper Scott Brown denied Mark Yeates in a goalless first half before Chris Westwood nodded in Ian Westlake's corner to put the Robins ahead.
Dean Hammond headed Yeates' free-kick past Brown to level before substitute John Finnigan received a second yellow card only six minutes after coming on.
Gillespie headed the U's in front and Yeates' low shot rounded off the win.
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Colchester: Walker, Maybury, Baldwin, Reid, Jackson (White 28), Perkins (Gobern 65), Izzet, Hammond, Yeates, Vernon (Gillespie 58), Platt. Subs Not Used: Cousins, Wordsworth.
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