Former Leeds players Danny Graham and Michael Bridges scored as Carlisle secured a deserved win at Elland Road.
Graham, who was on loan at Leeds in 2006, swept in Cleveland Taylor's cross from close range to put Carlisle ahead.
Then, a mix-up between Leeds keeper Casper Ankergren and defender Lubo Michalik allowed Graham to play Bridges through to score from a narrow angle.
Fabian Delph had a penalty shout waved away while Luciano Becchio hit a post after the break as Leeds toiled.
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Carlisle: Krul, Raven, Livesey, Murphy, Liddle, Taylor (Bridge-Wilkinson 66), Thirlwell, Kavanagh, Jeff Smith, Graham, Bridges (Dobie 59). Subs Not Used: Williams, Hackney, Keogh.
Booked: Jeff Smith, Thirlwell, Graham, Kavanagh.
Goals: Graham 26, Bridges 35.
Att: 22,411
Ref: Kevin Friend (Leicestershire).
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