Ali Gerba hit a brace as MK Dons cruised past Cheltenham, despite having to play an hour of the match with 10 men after Willy Gueret was sent off.
Gerba put Dons in front with a shot from 12 yards, before Gavin Caines equalised with a header.
Gueret was dismissed for violent conduct before Sam Baldock powered home a penalty, conceded by Lloyd Owusu.
Gerba converted from Jason Puncheon's pass before Owusu was sent off for a second bookable offence.
Milton Keynes Dons: Gueret, Cummings, Stirling, O'Hanlon, Lewington, Wright (Abbey 31), Leven, Belson (Navarro 65), Chadwick (Puncheon 78), Baldock, Gerba.Subs Not Used: Llera, Gallen.
Sent Off: Gueret (30). Booked: Stirling.
Goals: Gerba 9, Baldock 55 pen, Gerba 80.
Cheltenham: Scott P Brown, Kenton, Gallinagh, Caines, Wright, Murray, Payne (Ridley 51), Westlake, Hayes (Vincent 23), Fleetwood (Connor 65), Owusu.Subs Not Used: Higgs, Lindegaard.
Sent Off: Owusu (83).
Booked: Payne, Owusu, Westlake.
Goals: Caines 26.
Att: 8,190.
Ref: Graham Scott (Devon).
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