Leicester moved top of League One thanks to Lloyd Dyer's second-half winner against Colchester.
U's goalkeeper Dean Gerken denied Matty Fryatt twice in quick succession just before half-time.
But Dyer broke the deadlock when he made ground down the left and fired home with a stinging 25-yard shot.
Leicester continued to press but the U's almost snatched a point when Mark Yeates rattled the post with a fierce free-kick with 10 minutes left.
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Booked: Platt.
Booked: Howard.
Goals: Dyer 49.
Att: 5,133
Ref: Dean Whitestone (Northamptonshire).
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