Colchester survived a Swindon rally to leave the County Ground with a win.
John Jackson's left-footed shot put the visitors ahead before he set up Scott Vernon to score from close range.
Swindon striker Simon Cox pulled one back with a penalty after a Matt Heath handball before Billy Paynter hit the woodwork with a header.
Cox pounced on the rebound but keeper Dean Gerken pushed his effort wide as the U's recovered and secured a win with Sunday-Akanni Wasiu's strike.
Swindon: Brezovan, Jack Smith, Ifil, Aljofree, Kanyuka, McGovern (Marshall 46), Timlin (Easton 46), Nalis (Peacock 76), McNamee, Paynter, Cox. Subs Not Used: Phil Smith, Amankwaah.
Booked: Ifil.
Goals: Cox 67 pen.
Colchester: Gerken, White, Reid, Heath, Lockwood, Yeates, Izzet (Hammond 76), Jackson, Wordsworth, Platt, Vernon (Wasiu 85). Subs Not Used: Cousins, Coyne, Elito.
Booked: Wordsworth, Izzet.
Goals: Jackson 32, Vernon 45, Wasiu 89.
Att: 7,031
Ref: Clive Penton (Sussex).
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