Barnsley 0-2 Manchester United: Despite fielding a second-string side, it takes the cup holders less than six minutes to take the lead at Oakwell through striker Danny Welbeck
Michael Owen sends a timely nudge to England manager Fabio Capello with a superb finish in the 59th minute, although a second-half Gary Neville red card tempers the victory
Blackburn 5-2 Peterborough: A handful of travelling support at Ewood Park take extra precautions following the news that three Blackburn players have contracted swine flu
The masks hide the frowns, however, as Blackburn take the lead through Morten Gamst Pedersen in the fourth minute, but Chris Whelpdale is mobbed by his team-mates following equaliser 13 minutes later
But former Spain international Michel Salgado noses Blackburn in front at 3-2 with his first goal for the club in the 57th minute
Benni McCarthy adds a fourth before Nicola Kalinic rounds off the scoring from the penalty spot 16 minutes from time
Portsmouth 4-0 Stoke: Frederic Piquionne finds the back of net for the second time in the competition with a 17th-minute strike
The on-loan Frenchman adds his second of the match with one of the easier goals of his career to put the result beyond their Premier League opponents
Sunderland 0-0 Aston Villa (Villa win 1-3 on penalties): Despite his best efforts, striker Kenwyne Jones cannot find a way through Villa's obdurate defence at the Stadium of Light
Daryl Murphy does his best to put the home side in front, but James Collins - like Villa's defence - stands firm to force the game into extra time
Goalkeeper Brad Guzan is Villa's hero, saving a Jones spot-kick in the 83rd minute before stopping three in the shoot-out
But it's heartbreak for opposite number Craig Gordon as Ashley Young scores the penalty which takes Villa into the quarter-finals
Tottenham 2-0 Everton: A rasping 30th-minute strike from the edge of the area by midfielder Tom Huddlestone sees the home side take a 1-0 half-time lead at White Hart Lane
Despite his quizical gesture, striker Robbie Keane doubles Spurs' lead 12 minutes into the second half as the 2008 champions make the most of their goal-scoring opportunities
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