Jamie Ward's late winner gave Sheffield United all three points at Southampton.
Ward's low strike in the dying seconds stunned the Saints just moments after Andrew Surman's fierce shot appeared to have given the hosts a deserved point.
The Blades had taken the lead in the first half through Greg Halford, who headed home Nick Montgomery's cross.
The Saints dominated after United's Darius Henderson saw red for a clash with Jan-Paul Saeijs but were unable to break through until the late drama.
The crowd of 13,257 was the lowest league attendance at St Mary's.
Southampton boss Mark Wotte:
"A point does nothing for us and we needed three points so I had to push people forward and we got caught out.
"We have not lost the war tonight, we have only lost a battle and we have to keep on fighting.
"Every game is massive for us from now on and we need to win them all."
Sheffield United boss Kevin Blackwell:
"Jamie took his goal superbly well and we were delighted to see the ball fly in off the post.
"There was a lot of competition to sign him (from Chesterfield) in January but we are pleased to have got him.
"My lads showed tremendous spirit and I thought we deserved it."
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