Birmingham remain three points behind Championship leaders Wolves after Lee Carsley's solitary strike secured victory over a dominant Plymouth.
The home side wasted a number of chances with Paul Gallagher, Marcel Seip and Krisztian Timar going close.
But against the run of play, Carsley put Birmingham ahead with a rasping drive from outside the box.
Simon Walton's fierce effort forced Maik Taylor into a fine save and, late on, Rory Fallon missed a great chance.
Plymouth boss Paul Sturrock: "If there is a good way of losing then we have just played 90 minutes how you'd like it to happen.
"I am gutted for the players, but I am proud of every one of them. They gave everything they had and they played to the shape and the style we wanted.
"If we keep performing like that on a regular basis, we are going to win a lot more than we will lose."
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"We have come away with three points but we had to grind it out. We didn't have much in the first half, and we toiled a bit after half-time as well.
"We were always dangerous with speed up front and we got that breakthrough, a great strike from Lee Carsley."
Plymouth: Larrieu, Clark, Timar, Seip, Barker, Mackie, Summerfield (MacLean 90), Walton, Paterson (Noone 73), Gallagher, Fallon. Subs Not Used: Folly, Cathcart, Marin.
Booked: Fallon.
Birmingham: Maik Taylor, Hunt, Jaidi, Martin Taylor, Queudrue (Agustien 48), Parnaby, Quashie, Carsley, Owusu-Abeyie, Bent, Phillips (Jerome 67). Subs Not Used: Doyle, Nafti, Johnson.
Goals: Carsley 62.
Att: 10,446
Ref: Kevin Wright (Cambridgeshire).
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