Two errors from Reading goalkeeper Marcus Hahnemann cost his side as Preston came from behind to win.
The Royals went ahead when Noel Hunt was fouled by Sean St Ledger and the Irish striker's brother Stephen stepped up to score from the penalty.
But Preston equalised when Ivar Ingimarsson's header crept past his keeper Hahnemann for an own goal.
And the hosts grabbed the winner when Hahnemann missed Ross Wallace's corner and Stephen Elliott tapped in.
Preston manager Alan Irvine:"It was important for us that we matched Reading in all the qualities they have got.
"We have worked hard in the last two weeks which has been an opportunity for us to get back to things that we have done well in the past.
"If that means that has got us a result then it's fantastic."
Reading manager Steve Coppell:"We had a brilliant opportunity to get a point or points. We can only blame ourselves.
"We have no excuses other than our own frailty. This was an opportunity for us that we didn't take. I'm not blaming anyone, it happens.
"We have played a lot worse this year and won games."
Preston: Lonergan, Jones, Mawene, St. Ledger, McEveley, Sedgwick (Whaley 90), Nicholson, McKenna, Wallace (Jarrett 83), Parkin, Elliott (Mellor 90).Subs Not Used: Chris Neal, Nolan.
Booked: Wallace, Sedgwick.
Goals: Ingimarsson 55 og, Elliott 81.
Reading: Hahnemann, Rosenior, Bikey, Ingimarsson, Armstrong, Kebe, Karacan (Harper 84), Gunnarsson (Cisse 84), Stephen Hunt, Doyle (Long 68), Noel Hunt.Subs Not Used: Andersen, Kelly.
Goals: Stephen Hunt 27 pen.
Att: 12,316
Ref: Nigel Miller (Durham).
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