Wasps: Le Roux; Wade, Daly, Lovobalavu, Watson; Cipriani, Simpson; Mullan, Cruse, Cooper-Woolley, Launchbury (capt), Symons, Rieder, Thompson, Hughes.

Replacements: Johnson, McIntyre, Moore, Rowlands, Haskell, Hampson, Miller, De Jongh.

Harlequins: Brown; Yarde, Marchant, Roberts, Walker; Smith, Care; Marler, Ward, Sinckler, Merrick, Horwill (capt), Robshaw, Clifford, Luamanu.

Replacements: Elia Elia, Lambert, Collier, Glynn, South, Lewis, Swiel, Sloan.

Wasps have Lions centre Elliot Daly available for the first time following an extended pre-season break.

James Haskell is on the bench after finger surgery while winger Christian Wade is fit to return and Matt Mullan is recalled to the starting line-up.

Harlequins are without Joe Gray (broken thumb) and Demetri Catrakilis, who fractured bone in his throat in the win against Gloucester.

Mat Luamanu and Marcus Smith both start with Dave Ward moving to hooker.

From Wasps' late win at Worcester last Sunday, scrum-half Dan Robson (knee) and goal-kicker Jimmy Gopperth (foot) are ruled out with injuries while Dai Young's side are also missing James Gaskell, Kearnan Myall, Kyle Eastmond, Marcus Garratt, Sam Jones, Tommy Taylor, Thomas Young.

The last seven Premiership matches between these two clubs have all been won by the home side.

Wasps' only defeat in their last five Premiership games was last season's final to Exeter at Twickenham. They are on a club record run of 20 successive Premiership home wins at the Ricoh Arena.

Harlequins have won just two of their last six Premiership matches, both at home, but one of them was at Wasps' expense, 32-13 in Nick Evans' final home game at The Stoop in April.

Quins have not won away from home in the Premiership since a 30-27 victory at Gloucester on 4 March.

In case you missed it, Harlequins scrum-half Danny Care was on BBC Radio 5 live last week, talking about why it's so important for people to help out at grassroots level.

Recent research, external suggests there has been a fall of 18% since 2015 in people volunteering for community projects, including sports clubs.

Here he is, talking to Breakfast presenter Rachel Burden...

If you want to learn more about volunteering and how to get involved, check out our inclusive Get Inspired guide.

And if you know an unsung hero who volunteers in sport or activity in your community, why not nominate them for the BBC Sports Personality of the Year Unsung Hero award? Find out how, here.