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The latest round of Premier League fixtures kicks off with West Ham hosting Nottingham Forest in a relegation six-pointer on Tuesday (20:00 GMT).

Here is all the key injury news and essential Fantasy Premier League statistics before the 10 midweek games.

This article will be updated as Premier League managers give their weekly news conferences.

For more FPL help, don't miss our regular Friday Q&A from 15:30 GMT live on the BBC Sport website, with one of our four experts answering your questions

Tuesday

West Ham United v Nottingham Forest (20:00 GMT)

Argentine striker Taty Castellanos could make his West Ham debut after joining from Lazio, while fellow forward Pablo Felipe - who was an unused substitute against Wolves at the weekend - also awaits his first appearance following his move from Gil Vicente.

Jean-Clair Todibo and Lucas Paqueta are both doubtful after missing Saturday's defeat at Molineux through injury, while captain Jarrod Bowen is set to start his 200th Premier League game for the Hammers.

Nottingham Forest will continue to monitor winger Callum Hudson-Odoi, who sat out the defeat by Aston Villa because of an Achilles issue.

Goalkeeper John Victor was forced off at Villa Park with a calf problem and will also be assessed.

Players out: West Ham - Lukasz Fabianski, El Hadji Malick Diouf, Aaron Wan-Bissaka Nottingham Forest - Willy Boly, Ibrahim Sangare, Chris Wood, Ryan Yates

Doubts: West Ham - Lucas Paqueta, Jean-Clair Todibo Nottingham Forest - Callum Hudson-Odoi, Dan Ndoye, John Victor

Key FPL notes:

  • Jarrod Bowen (£7.7m) scored against Brighton in his last home appearance, earning seven points.

  • Alphonse Areola (£4.3m) has made a league-high 19 saves over the last four gameweeks, at least three more than any other goalkeeper.

  • Morgan Gibbs-White (£7.3m) has attempted 42 shots and created seven big chances. Both totals are more than any other Forest player this season.

Wednesday

Bournemouth v Tottenham Hotspur (19:30 GMT)

Bournemouth head coach Andoni Iraola says winger Antoine Semenyo, who is a transfer target for Manchester City, could make his final appearance for the Cherries on Wednesday.

The home side have lost Justin Kluivert, who requires knee surgery, while Ryan Christie is still sidelined.

Tottenham are expected to be without Mohammed Kudus, who injured his thigh against Sunderland on Sunday, but Xavi Simons returns from suspension.

Players out: Bournemouth - Tyler Adams, Ryan Christie, Ben Gannon-Doak, Will Dennis, Justin Kluivert, Veljko Milosavljevic Tottenham - Yves Bissouma, Mohammed Kudus, Dejan Kulusevski, James Maddison, Pape Matar Sarr, Dominic Solanke

Doubts: Tottenham - Destiny Udogie

Key FPL notes:

  • Justin Kluivert (£7.0m) has been unlucky not to register an assist recently, having created 13 chances for his team-mates over the last six gameweeks.

  • Despite blanking against Arsenal on Saturday, Marcus Tavernier (£5.6m) had four shots and created one chance.

  • Micky van de Ven (£4.5m) is Spurs' top-scoring player this season, earning 89 points thanks to three goals, one assist, seven clean sheets, 10 bonus points and four defensive contribution points.

Brentford v Sunderland

Brentford boss Keith Andrews has reported no new injury concerns.

Sunderland will monitor forward Wilson Isidor, who sustained a minor injury against Tottenham.

Dan Ballard made his return from an ankle injury as a substitute against Spurs and could come back into the starting line-up.

Head coach Regis Le Bris said there is a chance Reinildo Mandava could be involved following Mozambique's elimination from the Africa Cup of Nations.

Players out: Brentford - Fabio Carvalho, Josh Dasilva, Antoni Milambo, Frank Onyeka, Dango Ouattara Sunderland - Aji Alese, Habib Diarra, Arthur Masuaku, Noah Sadiki, Chemsdine Talbi, Bertrand Traore

Doubts: Sunderland - Wilson Isidor, Reinildo Mandava

Key FPL notes:

  • Igor Thiago (£6.9m) scored a hat-trick in Brentford's win at Everton and attempted six shots in total.

  • Nathan Collins (£4.9m) has quietly produced 35 points over the last five gameweeks, the joint-most of any FPL defender.

  • Brian Brobbey (£5.5m) has been directly involved in 67% of Sunderland's goals when on the pitch this season.

Crystal Palace v Aston Villa

Wing-back Nathaniel Clyne will miss Crystal Palace's next two games after being injured against Newcastle on Sunday.

Jefferson Lerma was also forced off at St James' Park and is ruled out by concussion protocol, meaning the Eagles are likely to be without 10 players for Wednesday's game.

Chris Richards is fit enough for a place on the bench but won't be able to start, according to boss Oliver Glasner.

Aston Villa will monitor centre-backs Pau Torres and Tyrone Mings, both of whom are nearing returns following injury lay-offs.

Mings has not played since 1 November while Torres has been sidelined for six matches.

Players out: Crystal Palace - Rio Cardines, Nathaniel Clyne, Cheick Doucoure, Daichi Kamada, Caleb Kporha, Jefferson Lerma, Daniel Munoz, Eddie Nketiah, Chadi Riad, Ismaila Sarr Aston Villa - Ross Barkley, Evann Guessand, Amadou Onana

Doubts: Aston Villa - Tyrone Mings, Pau Torres

Key FPL notes:

  • Jean-Philippe Mateta (£7.6m) scored and claimed a share of the bonus points to earn eight points in the corresponding fixture last season.

  • Marc Guehi (£5.3m) has already racked up six attacking returns this season, the joint-second highest figure of any FPL defender.

  • Ollie Watkins (£8.7m) has attempted 40 shots, including 16 big chances this season - both figures are the highest by a Villa player this season.

Everton v Wolverhampton Wanderers (19:30 GMT)

Everton boss David Moyes has no new injury issues, though six players remain unavailable through either injury or international duty.

Hwang Hee-chan and Joao Gomes were forced off with minor issues against West Ham on Saturday but boss Rob Edwards is hopeful both will be available.

Players out: Everton - Carlos Alcaraz, Jarrad Branthwaite, Seamus Coleman, Kiernan Dewsbury-Hall, Idrissa Gueye, Iliman Ndiaye Wolves - Emmanuel Agbadou, Jean-Ricner Bellegarde, Dan Bentley, Rodrigo Gomes, Toti Gomes, Marshall Munetsi

Doubts: Wolves - Joao Gomes, Hwang Hee-chan

Key FPL notes:

  • Jack Grealish (£6.5m) has created 36 chances for his team-mates this season, at least 12 more than any other Everton player.

  • Vitalii Mykolenko (£4.9m) provided an assist, kept a clean sheet and claimed two bonus points to earn 11 points in the corresponding fixture last season.

  • Mateus Mane (£4.5m) showcased his attacking potential with a goal and an assist in gameweek 20, finishing with a 12-point haul in the win over West Ham.

Fulham v Chelsea (19:30 GMT)

Fulham boss Marco Silva has reported no new injury concerns.

Calum McFarlane will take charge of a second game as Chelsea caretaker before new head coach Liam Rosenior begins work as Enzo Maresca's successor.

McFarlane is hopeful Robert Sanchez and Marc Cucurella, who were unavailable against Manchester City on Sunday, will return at Craven Cottage.

Wesley Fofana will also be assessed, while Moises Caicedo is set to reclaim his place in the starting line-up after serving a one-game ban.

Players out: Fulham - Calvin Bassey, Samuel Chukwueze, Alex Iwobi, Josh King, Rodrigo Muniz, Kenny Tete Chelsea - Levi Colwill, Dario Essugo, Romeo Lavia, Mykhailo Mudryk

Doubts: Fulham- Ryan Sessegnon Chelsea - Marc Cucurella, Wesley Fofana, Robert Sanchez

Key FPL notes:

  • Harry Wilson (£5.8m) has been Fulham's standout FPL performer this season, with 12 attacking returns in 17 starts and two substitute appearances.

  • Raul Jimenez (£6.2m) is a man in form, having registered four attacking returns from his last six appearances, amassing 28 points.

  • Enzo Fernandez (£6.4m) was one of Chelsea's biggest threats against Manchester City in gameweek 20, with three shots and two chances created.

Manchester City v Brighton & Hove Albion (19:30 GMT)

Brighton head coach Fabian Hurzeler says there is a small chance Yankuba Minteh could return from a muscle issue at the Etihad Stadium. However, Mats Wieffer remains out because of a toe injury.

Manchester City centre-back Ruben Dias injured his hamstring against Chelsea on Sunday and could be absent for up to six weeks.

Fellow defender Josko Gvardiol also faces a lengthy spell on the sidelines after fracturing his leg in the same game, though midfielder Nico Gonzalez is back in contention after missing out at the weekend.

Players out: Brighton - Carlos Baleba, Solly March, Stefanos Tzimas, Adam Webster, Mats Wieffer Manchester City - Rayan Ait-Nouri, Oscar Bobb, Ruben Dias, Josko Gvardiol, Mateo Kovacic, Omar Marmoush, Savinho, John Stones

Doubts: Brighton - Yankuba Minteh

Key FPL notes:

  • Erling Haaland (£15.1m) was unfortunate not to score in gameweek 20, having attempted five shots against Chelsea. The Norwegian is averaging 8.3 points per start on home turf this season.

  • Rayan Cherki (£6.8m) has produced one goal and eight assists in his last 11 matches, averaging 6.9 points per start.

  • Ferdi Kadioglu (£4.4m), started his 16th consecutive Premier League match on Saturday, banked the maximum bonus points to total nine points in gameweek 20.

Burnley v Manchester United (20:15 GMT)

Hannibal Mejbri is back in contention for Burnley following Tunisia's elimination from the Africa Cup of Nations.

Lyle Foster, whose South Africa side were also knocked out in the last 16, will be assessed following his return to England.

Darren Fletcher will lead Manchester United as caretaker boss against the Clarets following the departure of Ruben Amorim on Monday.

Fletcher says Bruno Fernandes and Mason Mount should both return from injury at Turf Moor though their minutes will need to be managed.

Players out: Burnley -Zeki Amdouni, Jordan Beyer, Josh Cullen, Zian Flemming, Axel Tuanzebe, Connor Roberts, Joe Worrall Manchester United -Amad, Noussair Mazraoui, Bryan Mbeumo

Doubts: Burnley - Maxime Esteve, Lyle Foster Manchester United - Matthijs de Ligt, Bruno Fernandes, Kobbie Mainoo, Mason Mount, Harry Maguire,

Key FPL notes:

  • Armando Broja (£5.2m) has produced 18 points over his last four appearances, registering one goal, one assist, two defensive contribution points and two bonus points.

  • Matheus Cunha (£8.2m) has taken 30 shots over the last six gameweeks, more than any other player.

  • Bruno Fernandes (£9.1m) has created 51 chances this season, more than any other player. The Portuguese is nearing a return from injury.

Newcastle United v Leeds United (20:15 GMT)

Newcastle winger Jacob Murphy was substituted against Crystal Palace on Sunday but a scan revealed no injury and head coach Eddie Howe is optimistic he will be available. However, this game comes too soon for Anthony Elanga.

Leeds captain Ethan Ampadu returns from a one-game ban. Head coach Daniel Farke has reported no new injury concerns and says fit-again midfielder Sean Longstaff could be on the bench against his former club.

Defenders Joe Rodon and Jayden Bogle are not yet fit to play, though both are making good progress, according to Farke.

Players out: Newcastle - Dan Burn, Anthony Elanga, Emil Krafth, Jamaal Lascelles, William Osula Leeds - Jayden Bogle, Dan James, Joe Rodon

Doubts: Newcastle - Jacob Murphy

Key FPL notes:

  • Bruno Guimaraes (£7.1m) is averaging 7.3 points per start on home turf this season, registering six goals, three assists and 14 bonus points.

  • Lewis Hall (£5.3m) has attempted 23 crosses over the last five gameweeks, the fourth-most of any FPL defender.

  • Brenden Aaronson (£5.4m) has produced one goal, three assists and 21 points in his last four appearances.

Thursday

Arsenal v Liverpool (20:00 GMT)

Arsenal are again without injured trio Cristhian Mosquera, Max Dowman and Riccardo Calafiori.

Manager Mikel Arteta says the fit-again Kai Havertz is "very close" to making his first appearance since August but added the club are carefully managing his workload.

Liverpool striker Hugo Ekitike missed Sunday's draw at Fulham because of what Arne Slot described as "delayed onset muscle soreness". The Reds will continue to assess the Frenchman.

Egypt's win against Benin in the last 16 of the Africa Cup of Nations means the Merseysiders are still without Mohamed Salah.

Players out: Arsenal - Riccardo Calafiori, Max Dowman, Cristhian Mosquera Liverpool - Wataru Endo, Alexander Isak, Giovanni Leoni, Mohamed Salah

Doubts: Liverpool - Hugo Ekitike

Key FPL notes:

  • Bukayo Saka (£10.2m) has seven assists already this season. Boosted by a share of set-pieces, he has created 16 chances over the last six gameweeks, the fourth-most of any player.

  • Jurrien Timber (£6.3m) is FPL's top defender for Expected Goal Involvements (xGI) in 2025-26, with 4.96.

  • Florian Wirtz (£8.2m) has registered attacking returns in three of his last four appearances, with 31 points banked over that period.

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