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Before the latest round of Premier League fixtures, here is all the key injury news alongside essential Fantasy Premier League statistics.

The gameweek kicks off with Manchester United at home to Manchester City at Saturday lunchtime (12:30 GMT) - here is the full fixture list.

This article will be updated as Premier League managers give their weekly news conferences.

For more FPL help, don't miss our regular Friday Q&A from 15:30 BST live on the BBC Sport website, with one of our four experts answering your questions

Saturday

Manchester United v Manchester City (12:30 GMT)

New Manchester United head coach Michael Carrick has Bryan Mbeumo and Amad Diallo back from the Africa Cup of Nations.

Noussair Mazraoui remains unavailable as he prepares for Sunday's final with host nation Morocco, while Shea Lacey is suspended.

Manchester City manager Pep Guardiola will make a late call on the fitness of Nico Gonzalez after training on Friday.

The game will come too soon for John Stones and Oscar Bobb.

Players out:Manchester United - De Ligt, Lacey, Mazraoui

ManchesterCity - Bobb, Dias, Gvardiol, Kovacic, Marmoush, Savinho, Stones

Doubts: City - Gonzalez

Key FPL notes:

  • No midfielder has created more chances than Manchester United captain Bruno Fernandes (£9.1m) this season, with 56.

  • United's Matheus Cunha (£8.1m) has racked up more shots than any other Fantasy midfielder in 2025/26 (58).

  • New City signing Antoine Semenyo (£7.6m) has produced four goals and one assist over the last six gameweeks while playing for Bournemouth, amassing 37 points.

Chelsea v Brentford (15:00 GMT)

Chelsea pair Cole Palmer and Reece James will be assessed after returning to training on Thursday. Liam Delap and Jamie Gittens have been ill and kept away from the main group.

Liam Rosenior provided no update on Malo Gusto at his press conference. The new head coach said last week he was "hopeful" the full-back would return for Brentford.

Jordan Henderson is in contention to play for Brentford despite an injury in the FA Cup last weekend.

Dango Ouattara is back from the Africa Cup of Nations but Frank Onyeka is still taking part.

Players out: Chelsea - Colwill, Essugo, Lavia, Mudryk Brentford - Carvalho, Dasilva, Milambo, Onyeka

Doubts: Chelsea - Delap, Gittens, Gusto, James, Palmer Brentford - Henderson

Key FPL notes:

  • After blanking in six straight gameweeks, Enzo Fernandez (£6.4m) has found some form. The Argentine has netted two goals in his last three matches and, over the season, is Chelsea's second-highest FPL points-scorer, with 92.

  • Igor Thiago (£7.1m) has scored five goals and provided an assist across his last four matches for Brentford. This season, only Erling Haaland (£15.1m) has scored more goals than the Brazilian's 16.

  • No player has amassed more points than the 44 of Brentford's Nathan Collins (£5.0m) since gameweek 17, thanks to a goal, two assists, three clean sheets, five bonus and four defensive contribution points.

Leeds United v Fulham (15:00 GMT)

Joe Rodon, Jayden Bogle, Sebastiaan Bornauw and Gabriel Gudmundsson are all available again for Leeds.

Dan James is their only current injury absentee.

Fulham are still missing Calvin Bassey, Alex Iwobi and Samuel Chukwueze due to their Africa Cup of Nations commitments.

Kenny Tete and Rodrigo Muniz are still out with injuries but manager Marco Silva said Josh King could be back for the trip to Elland Road.

Players out: Leeds - James Fulham - Bassey, Chukwueze, Iwobi, Muniz, Tete

Doubt: Fulham - King

Key FPL notes:

  • Leeds forward Dominic Calvert-Lewin (£6.0m) has produced eight goals since gameweek 13, the most of any FPL player.

  • Anton Stach's (£4.9m) 41 chances created and 29 successful crosses are both team-leading totals for Leeds.

  • Since gameweek 13, only one player has amassed more FPL points than Harry Wilson (£5.9m), with 66. The Welshman also recorded a goal and an assist in Fulham's FA Cup win last weekend.

Liverpool v Burnley (15:00 GMT)

Liverpool right-back Conor Bradley has been ruled out for the season and Mohamed Salah is still at the Africa Cup of Nations.

Burnley boss Scott Parker said Joe Worrall is close to making his comeback. Zian Flemming is also making progress, but won't be available at Anfield.

Hannibal Mejbri, Lyle Foster and Axel Tuanzebe have been back with the squad for a week after returning from the Africa Cup of Nations.

Players out: Liverpool - Bradley, Endo, Isak, Leoni, Salah Burnley - Amdouni, Beyer, Cullen, Flemming

Doubt: Burnley - Worrall

Key FPL notes:

  • With Conor Bradley (£5.0m) out for the season, positional rival Jeremie Frimpong (£5.7m) looks well-placed to benefit at Liverpool. Since returning from injury in gameweek 17, he has averaged 5.0 points per match thanks to three assists and two clean sheets.

  • Florian Wirtz's (£8.2m) last five appearances for Liverpool have harvested two goals, one assist, nine bonus and 34 points.

  • Since gameweek 17, Josh Laurent (£4.8m) has been Burnley's highest points scorer (24). The midfielder has delivered eight defensive contribution points during that period.

Sunderland v Crystal Palace (15:00 GMT)

Arthur Masuaku and Bertrand Traore will both be missing for Sunderland after picking up injuries at the Africa Cup of Nations.

Chemsdine Talbi and Habib Diarra are still at the competition but Noah Sadiki and Reinildo Mandava have returned and are in contention to play against Palace. Brian Brobbey is also fit after an ankle knock at Everton in the FA Cup.

Crystal Palace will be without Marc Guehi as he nears a transfer to Manchester City. Ismaila Sarr is at the Africa Cup of Nations with Senegal.

Jefferson Lerma is out of the concussion window and is available to play again.

Players out: Sunderland - Alese, Diarra, Masuaku, Talbi, Traore Palace - Cardines, Doucoure, Guehi, Kamada, Kporha, Nketiah, Riad, Sarr

Doubts: Palace - Clyne, Munoz

Key FPL notes:

  • Sunderland's Robin Roefs (£4.9m) remains the top-scoring goalkeeper in FPL with 95 points. Only one shot-stopper has made more than his 73 saves in 2025-26.

  • Over the last six gameweeks, only three defenders have produced more points than Sunderland's Nordi Mukiele (£4.4m), with 36.

  • Among players in his position, Crystal Palace centre-back Maxence Lacroix (£5.1m) ranks fourth for defensive contribution points (24), with a 61.9% success rate over the season.

Tottenham Hotspur v West Ham (15:00 GMT)

Tottenham will be without Richarlison for up to seven weeks because of a hamstring problem.

Lucas Bergvall will "probably" be fit for the visit of West Ham, according to head coach Thomas Frank. Yves Bissouma is back from the Africa Cup of Nations but has not featured for Spurs at all this season.

West Ham full-back El Hadji Malick Diouf is still on international duty.

Head coach Nuno Espirito Santo said Konstaninos Mavropanos, Mateus Fernandes and Lucas Paqueta are all doubts.

Players out: Tottenham - Kudus, Kulusevski, Maddison, Richarlison,Sarr West Ham - Diouf

Doubts: West Ham - Fernandes, Mavropanos, Paqueta

Key FPL notes:

  • Joao Palhinha (£5.5m) has produced six attacking returns (three goals, three assists) in 2025-26, the third-most of any Tottenham Hotspur player.

  • Since gameweek 18, only three FPL defenders have earned more points than the 24 by Spurs' Micky van de Ven's (£4.6m), thanks to an assist, two clean sheets, two defensive contribution points and five bonus.

  • Jarrod Bowen (£7.7m) has produced only three goals and an assist in the last eight gameweeks, but only two forwards have registered more shots in the box than the West Ham man's 21 during that period.

Nottingham Forest v Arsenal (17:30 GMT)

Nottingham Forest welcomed Willy Boly and Ibrahim Sangare back this week after Ivory Coast's elimination from the Africa Cup of Nations but head coach Sean Dyche said the pair are "recovering from travelling".

Goalkeeper John Victor is out and set for surgery but Ryan Yates is back in training.

Oleksandr Zinchenko, on loan from Arsenal, is ineligible for the game and Dyche has admitted the deal could be cancelled.

Arsenal manager Mikel Arteta believes Riccardo Calafiori, Max Dowman, Piero Hincapie and Cristhian Mosquera "might be" fit for the trip to Forest.

Arsenal have no new fitness concerns otherwise.

Players out: Nottingham Forest - Victor, Wood, Zinchenko

Doubts: Nottingham Forest - Boly, Sangare, Yates Arsenal - Calafiori, Dowman, Hincapie, Mosquera

Key FPL notes:

  • After going seven gameweeks without a goal, Morgan Gibbs-White (£7.3m) has now scored in back-to-back matches for Forest, amassing 17 points.

  • Despite missing six matches due to injury, Gabriel Magalhaes (£6.7m) is FPL's top-scoring defender with 112 points, having produced two goals and two clean sheets for Arsenal in his last three matches.

  • Since gameweek 16, no FPL midfielder has delivered as many assists (five) as Arsenal's Bukayo Saka (£10.2m).

Sunday

Wolverhampton Wanderers v Newcastle United (14:00 GMT)

Wolves welcome back Emmanuel Agbadou from the Africa Cup of Nations.

Head coach Rob Edwards confirmed Tawanda Chirewa is a doubt due to illness.

Newcastle United defender Fabian Schar had ankle surgery this week that will rule him out until the spring.

Jacob Murphy is also out after suffering a hamstring issue during the League Cup semi-final first leg loss to Manchester City. Emil Krafth and Tino Livramento are injured too, but Dan Burn and Will Osula are close to full fitness.

Players out: Wolves -Rodrigo Gomes, Bellegarde, Gomes Newcastle - Krafth, Livramento, Schar

Doubts: Wolves -Chirewa Newcastle - Burn, Osula

Key FPL notes:

  • Budget forward Mateus Mane (£4.5m) has scored two goals and provided an assist in his last two matches for Wolves, with 21 points.

  • Bruno Guimaraes (£7.2m) has recorded double-digit hauls in each of the last three Gameweeks for Newcastle United.

  • Harvey Barnes (£6.1m) has scored two goals in his last two matches and is Newcastle's leading goalscorer (11) in all competitions this season.

Aston Villa v Everton (16:30 GMT)

Aston Villa head coach Unai Emery says Boubacar Kamara might be sidelined for a "long time" because of the knee injury he sustained in the FA Cup. Alysson is not ready to play yet after his January transfer.

Emiliano Martinez is set to be assessed before the game, while Evann Guessand is back from the Africa Cup of Nations.

Everton manager David Moyes does not expect anyone on the injury list to return on Sunday, meaning eight first-team players are set to miss out.

Jack Grealish will be available again after serving a one-game suspension.

Players out: Aston Villa - Barkley, Kamara, Onana Everton - Alcaraz, Branthwaite, Coleman, Dewsbury-Hall, Gueye, Iroegbunam, Keane, Ndiaye

Key FPL notes:

  • Ollie Watkins (£8.8m) has produced eight attacking returns since the start of December. In that time, no forward has been presented with more big chances (12).

  • Since Gameweek 16, no FPL midfielder has surpassed Morgan Rogers' (£7.7m) 40 FPL points.

  • Only eight FPL midfielders have accrued more FPL points than James Garner (£5.1m) this season, with 95. This is partly due to his ability to bank defensive contribution points, having reached the threshold 10 times in 2025/26.

Monday

Brighton & Hove Albion v Bournemouth (20:00 GMT)

Brighton & Hove Albion have Carlos Baleba back from the Africa Cup of Nations.

Head coach Fabian Hurzeler said Yankuba Minteh is in contention again too after a dead leg.

Mats Wieffer is still out and Hurzeler added: "We had some players who were sick during this week...they will be an option for the game," he said.

Bournemouth head coach Andoni Iraola said Ryan Christie is the only player who will potentially return from those injured.

David Brooks twisted his ankle during the FA Cup loss to Newcastle United and is a fresh doubt.

Players out: Brighton - March, Tzimas, Webster, Wieffer Bournemouth - Adams, Christie, Gannon-Doak, Dennis, Kluivert, Milosavljevic

Doubt: Bournemouth - Christie

Key FPL notes:

  • With Justin Kluivert (£7.0m) injured and Antoine Semenyo at Manchester City, the responsibility may fall on Marcus Tavernier (£5.5m) to inspire Bournemouth in the coming weeks. The midfielder has struck four goals and provided three assists in 2025/26 thus far.

  • Since gameweek 16, no FPL midfielder has had as many big chances as the eight of Bournemouth's David Brooks (£5.0m).

  • Having only recently returned from injury, Kaoru Mitoma (£6.1m) scored his second goal of the campaign for Brighton against Manchester City in gameweek 21. Upcoming opponents Bournemouth are bottom for Expected Goals Against (xGA) in away matches this season.

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