Darren Lavery scored his third goal in as many games as Berwick beat 10-man Queen's Park.
The home side were immediately on the front foot, and Ross Drummond's shot was well-saved by William Muir.
It rebounded into the path of Blair Henderson who was poised to score before Scott Gibson handled the ball and sent off.
Lavery made no mistake from the spot, sending Muir the wrong way to notch his fourth of the season.
However, the home side were unable to build on their advantage and after some late pressure from Queen's Park were able to hold on to claim the three points.
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