The M1 has been closed in both directions in Leicestershire after a seven-vehicle pile-up, police have said.
Leicestershire Police said one person has been arrested after the crash between junctions 21A and 22 at about 18:40 GMT.
The Highways Agency said the motorway was expected to be closed until Wednesday morning.
It is not yet known if anyone has been injured.
The crash near the junctions for Leicester and Coalville involved a lorry and six cars, police said.
Police, fire and ambulance crews could remain on the scene until 10:00 GMT.
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