What is science for?
The Prime Minister will deliver a ringing endorsement of British science later today when he gives the prestigious Romanes Lecture in Oxford.
"We have a scientific record to be proud of," Gordon Brown will say. "The question now is how we build on this strength to make Britain the best country in the world in which to be a scientist".
And there's the rub. Few in the invited audience of the City's great and good will dispute the Prime Minister's assessment of Britain's great history of scientific achievement. Few will find fault with his ambition to ensure we produce the great scientists of tomorrow. Fewer still will argue with his promise to protect science funding in the economic downturn.
The question hanging over the Sheldonian Theatre today is about what all this science is for, and whether Ministers can direct it to drive economic growth.
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It's a simple fact that the Government has transformed science funding over the last 10 years. By 2010/11 spending in real terms will have doubled to almost £6 billion.
But as the budget has swelled, so has the emphasis on tangible benefits and quantifiable results. Gordon Brown's vision, as both Chancellor and Prime Minister, has positioned science as a key driver of the UK economy, securing the country's place at the heart of a European knowledge economy.
The science minister Lord Drayson threw down the gauntlet at the Royal Society earlier this month when he claimed the time had come to make choices about the balance of investment in science "...as part of a clear economic strategy".
"Given that this global economic downturn is radically reshaping the economic strength of nations - and that other nations are making choices about which areas to focus on in order to drive future growth - shouldn't we do the same to boost the economic impact of our science base?"
For many this emphasis on applied research and measurable economic returns smacks of picking winners - the doomed industrial strategy of the 1970's.
It's notoriously difficult to predict the uses a scientific discovery will be put to before the research has been done, and without the speculative "blue skies" research to drive the whole process forwards there's a danger that scientific progress will grind to a halt.


I'm Tom Feilden and I'm the science correspondent on the Today programme. This is where we can talk about the scientific issues we're covering on the programme.