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Friday, 7 December, 2001, 15:11 GMT
Scientists claim heart disease link
Overweight people
About 20% of people in Scotland are overweight
Scientists in Edinburgh say they have conclusively proven the link between obesity, diabetes and heart disease.

A research team claims that the risk of heart disease can be significantly reduced by knocking out an enzyme which releases a steroid within fat cells.

And the researchers believe that their discoveries could radically change the way clinicians tackle what is thought to be the biggest killer in the western world.

The findings come after more than five years of work by the Edinburgh University team led by Professor Jonathan Seckl.

Prof Jonathan Seckl
Prof Jonathan Seckl led the research

They said that their research had identified that cortisol, a steroid which is produced inside fat cells, could be one of the primary sources of heart disease.

It found that the enzyme which produced it was two to three times more active in people with fat which collects around the middle of the body.

The team also suggested that drugs which inhibited the enzyme could be used to treat conditions like diabetes - and even prevent heart disease.

Prof Seckl said his team had been working on the research for a number of years in collaboration with the Beth Israel Deaconess Medical Centre and Harvard Medical School in Boston.

"We have made a significant advance in our understanding of obesity, diabetes and heart disease - and how we now approach the commonest causes of death in the western world," he said.

Research
The research took more than five years

Speaking to BBC Scotland, he added: "I think it would mean that people who had this risk, perhaps about 20% of the Scottish population, indeed the Western population, who have fat around the middle, that they might be able not to get the nasty consequences of the fat around the abdomen.

"Which is they would get much less of a risk of diabetes of high blood fats, maybe high blood pressure and as a consequence of that."

However, they still need to find a pharmaceutical company to work with to develop the drugs to prevent the enzyme's production.

The research was partly funded by the British Heart Foundation, but it has warned that it should not be seen as a cure in isolation.

The foundation's Ian Lowis said: "We should first take the steps ourselves to ensure that we can do as much as we can individually to make sure that we don't have to rely on drugs in order to keep ourselves healthy and reduce the risk of heart disease or other diseases."

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News image BBC Scotland's David Nisbet reports
"It's taken more than five years of research in Edinburgh to make this potentially significant breakthrough"
See also:

24 May 01 | Health
New drug to beat obesity
30 May 01 | Health
Obesity epidemic warning
01 Jun 01 | Health
Anti-obesity drug 'works well'
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