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| Monday, 23 September, 2002, 15:47 GMT 16:47 UK Your genetic code on a disc ![]() Human genome: Instructions needed to make a person A British company says it is close to perfecting a gene sequencing method that could "read" someone's genome in a day.
Dr Venter says he will be able to provide an individual's genome on a CD in about a week for $712,000 (�400,000) from later this year. The data could reveal whether someone has genes that give them a higher risk of developing diseases such as Alzheimer's. It might even give an idea of how and when they will die. Cheaper, quicker The British company, Solexa, was set up by two Cambridge University chemists. It says it has developed a quicker, cheaper method to sequence human DNA.
These minute differences could explain why some people are predisposed to diseases such as cancer and diabetes, while others are not. Solexa's ultimate goal is to sequence an individual's entire genome in 24 hours for $1,000 (�562). Chief executive officer, Nick Mc Cooke, envisages a scenario where you would visit your GP for a blood test and get a complete map of your genetic code. He says such information could potentially improve human health but must be interpreted properly by a health professional. "It is possible to contemplate at some point in the future that your complete code is kept confidentially with the rest of your medical records," he told BBC News Online. "It would shed light on your genetic predisposition to disease and response to certain medications." Ethical concerns Genewatch UK, an independent pressure group, says there is an urgent need for better regulation of genetic testing. "The interpretation of what it means for your future is highly uncertain and often disputed," said Deputy Director, Dr Helen Wallace. "We wouldn't like to see any company marketing this kind of test until a regulation exists to check whether that test is valid or useful." The human genome is a string of three billion DNA "letters", comprising all the instructions needed to build and maintain a human being.
The effort, which took many years, was carried out by an international public consortium of scientists and a private US company, Celera, headed by Dr Venter, who has now stepped down. The DNA came from a small number of undisclosed individuals, who are currently the only people in the world to have had their genomes sequenced. However, Dr Venter recently revealed that his DNA was among the samples used in the Celera work. |
See also: 18 Feb 01 | San Francisco 23 Nov 99 | Science/Nature 07 Jul 01 | Science/Nature 11 Feb 01 | Science/Nature 22 Jan 02 | Science/Nature 30 May 00 | Human genome Internet links: The BBC is not responsible for the content of external internet sites Top Science/Nature stories now: Links to more Science/Nature stories are at the foot of the page. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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