EuropeSouth AsiaAsia PacificAmericasMiddle EastAfricaBBC HomepageWorld ServiceEducation
News image
News image
News image
News imageNews image
News image
Front Page
News image
World
News image
UK
News image
UK Politics
News image
Business
News image
Sci/Tech
News image
Health
News image
Education
News image
Sport
News image
Entertainment
News image
Talking Point
News image
In Depth
News image
On Air
News image
Archive
News image
News image
News image
Feedback
Low Graphics
Help
News imageNews imageNews image
News imageMonday, October 25, 1999 Published at 12:18 GMT 13:18 UK
News image
News image
Health
News image
Pig cells mend damaged spines
News image
The breakthrough could lead to a treatment for spinal injuries
News image
Transplanting genetically-modified pig cells into monkeys with damaged spines helped repair the damage which causes paralysis in humans, experts report.

The researchers from the Yale University School of Medicine in the US believe this is a significant move towards a treatment for people with spinal cord injuries.

The GM cells were able to stimulate the production of myelin, the protein which forms a sheath spinal nerves and allows them to conduct electrical nerve messages to and from the brain.

The experiments were carried out on primates whose spinal cords had been deliberately damaged.

Alexion Pharmaceuticals, which is funding the research, is confident that trials on humans may now have moved a step closer.

Ethical dilemma

However, the transplantation of animal tissue into humans, or xeno-transplantation, will involve overcoming major ethical and clinical barriers.


[ image: The cells would be taken from GM pigs]
The cells would be taken from GM pigs
Many fear that the husbandry procedures needed to raise pigs for xeno-transplantation use involve extremely inhumane practices.

And there are still worries that unknown viruses previously restricted to the animal population could be spread into humans.

In the UK, experts discussing possible safeguards for xeno-transplantation have suggested that people receiving animal tissue would have to agree never to have children, or even unprotected sex.

However, the US scientists are upbeat about the results.

Stephen Squinto, from Alexion, said: "This promising data demonstrates that immunoprotected transgenic pig cells can survive and regenerate myelin sheaths around damaged neurones within the spinal cords of non-human primates.

"It suggests that this approach may lead to the development of a new therapy for spinal cord injury patients."

The major obstacle to the use of animal tissue in humans is the body's immune response, which identifies foreign matter and destroys it.

The scientists managed to genetically modify the pig cells so that the level certain sugars on the cell which trigger an immune system attack is reduced or even eliminated.

Also, the surface of the cells was covered with proteins that act to hold back an immune response.

'Treatment milestone'

Dr Jeffrey Kocsis, who led the study, said it represented a "particularly important milestone."

Treatments for people with spinal cord injuries are currently extremely limited.

Spinal injuries causes paralysis, or loss of some function, proving more disabling the higher up the spine they occur.

Neck injuries can causes loss of sensation and motor function in all four limbs, and in the most severe cases, even the ability to breathe unaided can be affected.



News image


Advanced options | Search tips


News image
News image
News imageBack to top | BBC News Home | BBC Homepage |
News image

News imageNews imageNews image
Health Contents
News image
News imageBackground Briefings
News imageMedical notes
News imageNews image
Relevant Stories
News image
30 Sep 99�|�Health
Baboon virus passed to transplant patient
News image
19 Aug 99�|�Sci/Tech
Pig transplants 'safe for humans'
News image
22 Jul 99�|�Health
Medicinal cannabis grower acquitted
News image
25 Oct 99�|�Health
Virus warning over animal organ transplants
News image
25 Oct 99�|�Health
Animal transplant patients face child ban
News image

News image
News image
News image
News imageInternet Links
News image
News imageNews image
Spinal Injuries Association
News image
National Spinal Cord Association (US)
News image
News imageNews image
The BBC is not responsible for the content of external internet sites.

News image
News image
News image
News imageIn this section
News image
Disability in depth
News image
Spotlight: Bristol inquiry
News image
Antibiotics: A fading wonder
News image
Mental health: An overview
News image
Alternative medicine: A growth industry
News image
The meningitis files
News image
Long-term care: A special report
News image
Aids up close
News image
From cradle to grave
News image
NHS reforms: A guide
News image
NHS Performance 1999
News image
From Special Report
NHS in crisis: Special report
News image
British Medical Association conference '99
News image
Royal College of Nursing conference '99
News image

News image
News image
News image