Hormones influence brain function

A team from the University of Newcastle is looking for volunteers to test the pill before they embark on a more detailed study of the effect on depression.

The key ingredient is a hormone called DHEA, which occurs naturally, but decreases with age - and is often found at lower levels in people who are depressed.

DHEA, which is produced by the adrenal glands, is thought to neutralise the effects of the stress hormone cortisol.

It is also thought to slow the effects of ageing, and boost brain functions such as memory and mood.

The Newcastle team plan to subject volunteers to a battery of memory and accuracy tests.

Dr Hamish McAllister-Williams, who is leading the research, said: "Research into the effect of DHEA has been inconclusive, but it may improve mood and memory and cause subtle changes to the way the brain works.

It is important to remember that the best treatment for depression is usually a holistic package of care Amelia Mustapha

"People with depression tend to higher levels of cortisol and lower levels of DHEA, which seems to make them more prone to memory impairment

"If we can give them more DHEA, we may be able to counter some of the effects of depression."

Amelia Mustapha, of group Depression Alliance, told BBC News Online: "Many people with depression experience problems with memory and concentration and this can severely impair their functioning in quotidian (everyday) life.

"The results of this research may help clinicians to understand and treat these particular symptoms and of course, this is to be welcomed.

"However, it is important to remember that the best treatment for depression is usually a holistic package of care, which looks at the biological, psychological and social aspects of the illness.

"We hope that this research will lead to more choice in treatments for people affected by depression."

DHEA is not currently licensed in the UK. However, in the US it is available over-the-counter at pharmacies.