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| Friday, 2 August, 2002, 00:19 GMT 01:19 UK Scientists unravel secrets of long life ![]() The research is based on a group of 1,500 people In a study published in the journal Science, they report that the length of a person's life is related to their body temperature, and to levels of two chemicals, insulin and DHEAS, circulating in the blood.
The researchers are not entirely sure of the reasons behind this finding but experiments with animals suggest it may be to do with a lower metabolic rate. They say that unravelling the mechanisms behind the finding may lead to new ways of helping people to live longer. Of mice and men The suggested link between lifespan and metabolic rate comes from experiments in which animals are maintained on strict calorie-controlled diets. These animals tend to live longer than normal - up to 40% longer. They also have lower than average body temperature, low levels of insulin, and high levels of dehydroepiandrosterone sulphate (DHEAS). George Roth from the National Institute of Ageing in Baltimore in the United States has been working on a long-term study of factors affecting human lifespan. Called the Baltimore Longitudinal Study of Ageing, it has been running since 1958 and has enrolled around 1,500 people. Longevity clues Following the lead given by the animal diet experiments, Dr Roth's team decided to analyse body temperature and levels of insulin and DHEAS in men enrolled in the Baltimore study. "Men with lower temperature and insulin and those maintaining higher DHEAS levels have greater survival than respective counterparts," he writes in the Science journal. At present, there are not enough data to say precisely how big these effects are. The average human body temperature is around 37 degrees Celsius but individuals differ by around a degree. The men in the Baltimore study are not on diets. So something else must be keeping body temperature and insulin down, and DHEAS up, in the men who are living longer. "It could be genetic, it could be something else in their lifestyle apart from diet," Dr Roth told the BBC. "If we can learn what these individuals are doing then perhaps we could help the rest of us to live longer, too." | See also: 29 Jul 02 | Health 15 Jul 02 | Health 04 Jul 02 | England 09 May 02 | Health 18 Feb 02 | Boston 2002 17 Feb 02 | From Our Own Correspondent 05 Apr 01 | Health Internet links: The BBC is not responsible for the content of external internet sites Top Health stories now: Links to more Health stories are at the foot of the page. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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