BBC NEWSAmericasAfricaEuropeMiddle EastSouth AsiaAsia Pacific
BBCiNEWS  SPORT  WEATHER  WORLD SERVICE  A-Z INDEX    

BBC News World Edition
 You are in: Health 
News Front Page
Africa
Americas
Asia-Pacific
Europe
Middle East
South Asia
UK
Business
Entertainment
Science/Nature
Technology
Health
Medical notes
-------------
Talking Point
-------------
Country Profiles
In Depth
-------------
Programmes
-------------
BBC Sport
News image
BBC Weather
News image
SERVICES
-------------
EDITIONS
Saturday, 27 July, 2002, 23:01 GMT 00:01 UK
Viruses help make 'deadlier bacteria'
Petri dish
Bacteria can be targeted by viruses
Viruses which target bacteria could be helping produce deadlier strains - but also provide ways to tackle disease, say experts.

These viruses, called bacteriophages, do not invade human cells - instead, they replicate in specific bacteria.

However, their genetic manipulation of the host bacterium can leave it stronger than before.


There is real potential to use bacteriophages in therapies in the future

Dr Mike Bailey, University of Oxford
Scientists from the US National Institute of Allergy and Infectious Diseases looked at a bacterium called group A streptococcus.

This common microbe can cause a wide variety of illnesses, ranging from sore throats and scarlet fever to "flesh-eating" necrosis and toxic shock.

The researchers focused on a particular strain - called M3 - which causes a particularly invasive infection and serious disease.

They examined its genetic code to see what made it different from its less virulent streptococcus cousins.

They found that 90% of its genes were shared with the other strep strains, but that the last 10% were unique to the highly-toxic M3.

Looking more closely at these sections of genetic code, the scientists spotted telltale signs which linked them to bacteriophages.

Swapping genes

Viruses do not have any means of independent reproduction, as bacteria do.

Instead they rely on harnessing the reproductive capacity of their host cell to make copies of themselves.

During this process, it is possible that some of the bacteriophage's genetic code, perhaps some picked up from another organism, will be left behind in a surviving bacterial cell.

In some cases, these new genes will change the way the bacterium functions.

While often this will be to the disadvantage of the bacterium, occasionally the change will confer an advantage.

Harnessing the power

Evolution then takes over - a strain with such an advantage will prosper at the expense of other strains.

Professor Mark Bailey, an expert in virology and microbiology from the Centre for Ecology and Hydrology at Oxford University, said that gene-swapping between bacteriophages and many different types of bacteria was common.

He said that harnessing the power of bacteriophages could be key to future medicines.

"The beauty of these viruses is that they are so specific - they target only one type of bacteria and nothing else," he said.

"There is real potential to use bacteriophages in therapies in the future."

See also:

28 Sep 99 | Health
26 Sep 98 | Science/Nature
Internet links:


The BBC is not responsible for the content of external internet sites

Links to more Health stories are at the foot of the page.


E-mail this story to a friend

Links to more Health stories

© BBC^^ Back to top

News Front Page | Africa | Americas | Asia-Pacific | Europe | Middle East |
South Asia | UK | Business | Entertainment | Science/Nature |
Technology | Health | Talking Point | Country Profiles | In Depth |
Programmes