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| Thursday, 24 January, 2002, 00:42 GMT Scientists develop 'cloning alternative' ![]() Adult stem cells could be used to grow human tissue An American scientist may have discovered a cell in adults that can turn into every single tissue in the body. Until now, it was thought that only embryonic stem cells could do this. Anti-abortion groups, who object to embryology research on ethical grounds, have welcomed the news which is reported in New Scientist magazine.
The research has not been published in a scientific journal. However, it has been carried out by a highly respected team and received favourable reviews from those familiar with the work. Ihor Lemischka of the US's Princeton University said: "The work is very exciting. They can differentiate into pretty much everything that an embryonic stem cell can differentiate into." The cells were found in the bone marrow of adults by Catherine Verfaillie at the University of Minnesota. Scientific potential The cells, named multipotent adult progenitor cells (MAPCs), are said to have the same potential as embryonic stem cells (ESCs). Irving Weissman of the US's Stanford University said: "It's very dramatic the kinds of observations Verfaillie is reporting. The findings, if reproducible, are remarkable." Religious groups and "pro-family" organisations in the UK are among those who regularly raise concerns about the ethics of using embryo clones. Tom Horwood from the Catholic Church said: "Over the last couple of years, researchers on both sides of the Atlantic have been looking at adult stem cells, so that's very much to be welcomed. "An option such as this which doesn't involve the deliberate production and destruction of life is much better. What it needs is more support and finance." The adult stem cells seem to grow indefinitely in culture, like ESCs. Ethical debate Some cell lines have been growing for almost two years and have kept their characteristics, with no signs of ageing, researchers claim. The discovery of such "versatile adult stem cells" is likely to fan the debate about whether embryonic stem cell research is justified. Anti-abortion groups argue the ethical concern is that the procedure involves creating an embryo for the sole purpose of providing a treatment for a disease. They claim the adult stem cell development demonstrates the alternatives to therapeutic cloning. They believe these alternatives have been constantly underplayed by the scientific community.
Verfaillie's team thinks MAPCs are rare cells present in the bone marrow that can be fished out through a series of enriching steps. But others think the selection process actually creates the MAPCs. Neil Theise of New York University Medical School said: "I don't think there is a cell that is lurking there that can do this. I think Catherine has found a way to produce a cell that can behave this way." Stem cell researchers say it is too early to tell whether the ultimate stem cell has been discovered and most believe research with embryonic stem cells must continue. |
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